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US 2017/0281573 A1Published application
Medicinal composition for enhanced delivery of triterpenes
AssigneesPharcon Corporation, RMW Pharma Consulting, Inc.
InventorsJoseph Schwarz, Michael Weisspapir
Life of this patent
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Abstract
The present disclosure relates to self-emulsifying oral compositions for enhanced absorption of poorly water soluble triterpenes, such as pentacyclic triterpene acids, either in substantially pure form or as a constituents of herbal extracts.
Claims20
A self-nanoemulsifying composition for enhanced oral absorption of poorly soluble triterpene acids, comprising:
- a. at least one substantially pure triterpene acid or at least one plant extract containing said triterpene acid in amount from about 0.01% to about 80% by weight of the composition;
- b. at least one physiologically acceptable aromatic solubilizer in amount from about 0.5% to about 80% by weight of the composition;
- c. at least one physiologically acceptable surfactant or mixture of surfactants in amount from about 0.5% to about 80% by weight of the composition;
- and
- d. at least one natural or synthetic phospholipid in amount from about 0.1% to about 50% by weight of the composition.
2 more elements
A self-nanoemulsifying composition administered via oral or intraoral routes,
- wherein the composition spontaneously forms a submicron oil-in-water emulsion when contacted with water containing media and wherein the composition comprises:
- a. a substantially pure pentacyclic triterpene acid or plant extract containing at least one pentacyclic triterpene acid in an amount of about 0.01 to 80% by weight of the composition;
- b. a physiologically acceptable hydrophobic material forming an oil phase of the emulsion on contact with water containing media or body fluid in an amount of about 5% to about 60% by weight of the composition, wherein the pentacyclic triterpene acid remains substantially dissolved in the oil phase of the emulsion;
- c. a physiologically acceptable surfactant or mixture of surfactants in an amount of about 0.5% to about 80% by weight of the composition;
- d. at least one natural or synthetic phospholipid in amount from about 0.1% to about 50% by weight of the composition;
- and
- e. D-, L-, racemic alpha-lipoic acid, mixture thereof or physiologically acceptable salts thereof in amount from about 1 to about 50% by weight of the composition.
4 more elements
A self-nanoemulsifying composition for enhanced oral absorption of poorly soluble triterpene acids, comprising:
- a. at least one pure triterpene acid or at least one plant extract containing said triterpene acid in amount from about 0.01% to about 80% by weight of the composition;
- b. at least one physiologically acceptable aromatic solubilizer in amount from about 0.5% to about 80% by weight of the composition;
- c. at least one physiologically acceptable surfactant or mixture of surfactants in amount from about 0.5% to about 80% by weight of the composition;
- d. at least one natural or synthetic phospholipid in amount from about 0.1% to about 50% by weight of the composition;
- and
- e. R-alpha-lipoic acid, S-alpha-lipoic acid, racemic alpha-lipoic acid or a physiologically acceptable salt thereof in amount from about 0.5% to about 50% by weight of the composition.
3 more elements
Dependencies are inferred from the claim text.