# US 2017/0281507 A1 · Peptides and Their Use in the Treatment of Skin > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2017/0281507 A1 - Document ID: US20170281507A1 - Status: Published application - Kind: A1 - Application number: 14/766,006 - Filed: 2014-12-23 - Published: 2017-10-05 - Earliest claimed: 2014-12-23 - Assignees: Avon Products, Inc. - Applicants: Avon Products, Inc. - Inventors: Jolanta Idkowiak-Baldys; John W. Lyga; Uma Santhanam - Web page: https://patentgrep.com/patent/US20170281507A1 ## CPC - A61K 8/64: Proteins; Peptides; Derivatives or degradation products thereof - A61K 8/06: Emulsions - A61K 8/342: {Alcohols having more than seven atoms in an unbroken chain} - A61Q 19/02: for chemically bleaching or whitening the skin - A61Q 19/08: Anti-ageing preparations - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS ## Abstract Provided are methods of diminishing the signs of aging and/or improving the health of human integuments, such as skin, and compositions useful therefor. The compositions according to the invention comprise a peptide having the sequence AECK (SEQ ID NO: 1) or a derivative thereof, in a topically acceptable vehicle. ## Claims ### Claim 1 A method for improving the health and/or appearance of human skin affected by dermatological signs of aging comprising topically applying to an area of skin in need thereof a composition comprising, in a topically acceptable vehicle, an effective amount of a peptide comprising the sequence AECK (SEQ ID NO: 1), AEC (SEQ ID NO: 2), or ECK (SEQ ID NO: 3) for a time sufficient to improve the appearance and/or health of said skin. ### Claim 2 (depends on 1) The method according to claim 1, wherein said peptide increases hyaluronic acid production in skin. ### Claim 3 (depends on 1) The method according to claim 1, wherein said improvement in the appearance of skin affected by dermatological signs of aging is selected from a group consisting of: (a) treatment, reduction, and/or prevention of fine lines and/or wrinkles; (b) reduction of skin pore size; (c) improvement in skin thickness, plumpness, and/or tautness; (d) improvement in skin smoothness, suppleness and/or softness; (e) improvement in skin tone, radiance, and/or clarity; (f) improvement in procollagen, and/or collagen production; (g) improvement in maintenance and remodeling of elastin; (h) improvement in skin texture and/or promotion of retexturization; (i) improvement in skin barrier repair and/or function; (j) improvement in appearance of skin contours; (k) restoration of skin luster and/or brightness; (l) replenishment of essential nutrients and/or constituents in the skin; (m) improvement of skin appearance decreased by aging and/or menopause; (n) improvement in skin moisturization; (o) increase in skin elasticity and/or resiliency; (p) treatment, reduction, and/or prevention of skin sagging; (q) improvement in skin firmness; and (r) reduction of pigment spots and/or mottled skin; and (s) improvement of optical properties of skin by light diffraction or reflection. ### Claim 4 (depends on 1) The method according to claim 1, wherein said improvement in the appearance of skin affected by dermatological signs of aging includes reduction in the fine lines and/or wrinkles. ### Claim 5 (depends on 1) The method according to claim 1, wherein said improvement in the appearance of skin affected by dermatological signs of aging includes reduction in skin sagging. ### Claim 6 (depends on 1) The method according to claim 1, wherein said improvement in the appearance of skin affected by dermatological signs of aging includes thickening of said skin. ### Claim 7 (depends on 1) The method according to claim 1, wherein said composition is applied at least once daily. ### Claim 8 (depends on 1) The method according to claim 1, wherein said composition is applied at least once daily for at least eight weeks. ### Claim 9 (depends on 1) The method according to claim 1, wherein said topically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion, and further comprises an emulsifier. ### Claim 10 (depends on 1) The method according to claim 1, wherein said effective amount is from about 0.000001% to about 5% by weight. ### Claim 11 (depends on 1) The method according to claim 1, wherein said area of skin comprises skin of the face. ### Claim 12 (depends on 1) The method according to claim 1, wherein said composition comprises an additional active ingredient selected from the group consisting of alpha-hydroxy acids, glycolic acid, thodipropionic acid or esters thereof, salicylic acid, N-acetyl tyrosinamide, phytol, and retinoids. ### Claim 13 (depends on 12) The method according to claim 12, wherein said composition comprises retinol. ### Claim 14 A composition comprising an effective amount of a peptide comprising the sequence AECK (SEQ ID NO: 1), AEC (SEQ ID NO: 2), or ECK (SEQ ID NO: 3) and a topically acceptable vehicle. ### Claim 15 (depends on 14) The composition of claim 14, wherein said effective amount is from about 0.00001% to about 5% by weight. ### Claim 16 (depends on 14) The composition of claim 14, wherein said effective amount is from about 0.00001% to about 0.001% by weight. ### Claim 17 (depends on 14) The composition of claim 14, wherein said topically acceptable vehicle comprises a water-in-oil, oil-in-water, silicone-in-water, or water-in-silicone emulsion and further comprises an emulsifier. ### Claim 18 (depends on 14) The composition of claim 14 further comprising an additional active ingredient selected from the group consisting of alpha-hydroxy acids, thiodipropionic acid or esters thereof, salicylic acid, niacinamide, hexyl resorcinol, phytol, and retinoids. ### Claim 19 (depends on 18) The composition of claim 18 further comprising retinol. ### Claim 20 (depends on 14) The composition of claim 14 further comprising at least one other ingredient selected from the group consisting of a film forming polymer, a thickener, a pH adjuster, a preservative, an emulsifier, a gelling agent, an antioxidant, an emollient, a humectant, a fragrance, and a colorant.