# US 2017/0281502 A1 · Oral composition for alleviation of dentin hypersensitivity

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- Number: US 2017/0281502 A1
- Document ID: US20170281502A1
- Status: Published application
- Kind: A1
- Application number: 15/507,115
- Filed: 2015-07-27
- Published: 2017-10-05
- Earliest claimed: 2014-08-29
- Assignees: Nof Corporation
- Applicants: Nof Corporation
- Inventors: Koji MIYAMOTO; Nobuyuki YAMAMOTO; Shunsuke SAKURAI; Yoshihisa SHIMAMURA
- Web page: https://patentgrep.com/patent/US20170281502A1

## CPC

- A61K 8/55: Phosphorus compounds
- A61K 8/24: Phosphorous; Compounds thereof
- A61K 8/34: Alcohols
- A61K 8/345: {containing more than one hydroxy group}
- A61K 8/8152: {Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers}
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 25/02: for peripheral neuropathies
- A61Q 11/00: Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
- C08F 230/02: containing phosphorus
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS

## Abstract

An oral composition for reducing dentinal hypersensitivity according to the present invention comprises a phosphorylcholine-containing polymer as an active ingredient. A general consumer can use the oral composition routinely in various forms. The oral composition is brought into contact with an oral cavity of a user to reduce the dentinal hypersensitivity.

## Claims

### Claim 1

An oral composition for reducing dentinal hypersensitivity comprising a phosphorylcholine-containing polymer as an active ingredient.

### Claim 2 (depends on 1)

The oral composition according to claim 1, wherein the phosphorylcholine-containing polymer comprises at least one polymer selected from the group consisting of homopolymers of 2-methacryloyloxyethyl phosphorylcholine, copolymers of 2-methacryloyloxyethyl phosphorylcholine and butyl methacrylate, copolymers of 2-methacryloyloxyethyl phosphorylcholine and stearyl methacrylate, and copolymers of 2-methacryloyloxyethyl phosphorylcholine and 2-hydroxy-3-methacryloyloxypropyl trimethyl ammonium chloride, and has a weight-average molecular weight of 10,000 to 10,000,000.

### Claim 3 (depends on 1)

The oral composition according to claim 1, comprising 0.001% to 10% by mass of the phosphorylcholine-containing polymer.

### Claim 4 (depends on 1)

The oral composition according to claim 1, having a pH of 5 to 11.

### Claim 5 (depends on 1)

The oral composition according to claim 1, further comprising at least one ingredient selected from the group consisting of glycerin, sorbitol, maltitol, and xylitol.

### Claim 6

Use of a phosphorylcholine-containing polymer for reducing dentinal hypersensitivity.

### Claim 7 (depends on 1)

A method for reducing dentinal hypersensitivity, comprising bringing the oral composition according to claim 1 into contact with an oral cavity of a user.