# US 2017/0281140 A1 · Methods and medical elongate bodies > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 2017/0281140 A1 - Document ID: US20170281140A1 - Status: Published application - Kind: A1 - Application number: 15/470,114 - Filed: 2017-03-27 - Published: 2017-10-05 - Earliest claimed: 2016-03-29 - Assignees: Terumo Kabushiki Kaisha - Applicants: Terumo Kabushiki Kaisha - Inventors: Shouta ARAHIRA; Hironori SHIGA; Kenji OYAMA; Yuusuke SEKINE - Web page: https://patentgrep.com/patent/US20170281140A1 ## CPC - A61B 1/3137: {for examination of the interior of blood vessels} - A61B 1/012: characterised by internal passages or accessories therefor - A61B 5/02158: {provided with two or more sensor elements} - A61B 5/6853: {with a balloon} - A61B 17/12036: {partial occlusion} - A61B 17/12045: {double occlusion, e.g. during anastomosis} - A61B 17/12109: {in a blood vessel} - A61B 17/12186: {liquid materials adapted to be injected} - A61B 17/320758: {with a rotating cutting instrument, e.g. motor driven (A61B17/320725, A61B17/32075 and A61B17/320783 take precedence; for removing intra-ocular material A61F9/00763; endoscopic rotatable cutting instruments A61B17/32002)} - A61L 27/507: {for artificial blood vessels (apparatus for applying cells on a blood vessel prosthesis A61F2/062)} - A61L 27/52: Hydrogels or hydrocolloids - A61M 25/1011: {Multiple balloon catheters} - A61B 17/12181: {formed by fluidized, gelatinous or cellular remodelable materials, e.g. embolic liquids, foams or extracellular matrices} - A61B 17/12195: {comprising a curable material} - A61B 17/3207: Atherectomy devices {working by cutting or abrading; Similar devices specially adapted for non-vascular obstructions (A61B17/32037 takes precedence; endoscopic cutting instruments A61B17/320016)} - A61B 17/320725: {with radially expandable cutting or abrading elements (A61B17/32075 takes precedence)} - A61B 2017/00623: {Introducing or retrieving devices therefor} - A61B 2017/22054: {with two balloons} - A61B 2017/22067: {Blocking; Occlusion (A61B2017/22054 takes precedence)} - A61B 2017/22081: {Treatment of vulnerable plaque} - A61B 2017/22082: {after introduction of a substance} - A61B 2017/22094: {for crossing total occlusions, i.e. piercing} - A61M 31/00: Devices for introducing or retaining media, e.g. remedies, in cavities of the body (A61M25/00 takes precedence {; introducing or retaining ophthalmic products into the ocular cavities A61F9/0008}) - A61M 2005/1787: {Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid} - A61M 2025/105: {having a balloon suitable for drug delivery, e.g. by using holes for delivery, drug coating or membranes} - A61M 2025/1052: {for temporarily occluding a vessel for isolating a sector} - A61M 2025/1081: {having sheaths or the like for covering the balloon but not forming a permanent part of the balloon, e.g. retractable, dissolvable or tearable sheaths} - A61M 2025/1084: {having features for increasing the shape stability, the reproducibility or for limiting expansion, e.g. containments, wrapped around fibres, yarns or strands} - A61M 2025/109: {having balloons for removing solid matters, e.g. by grasping or scraping plaque, thrombus or other matters that obstruct the flow} - A61M 2202/00: Special media to be introduced, removed or treated - A61M 2202/0007: introduced into the body - A61M 2202/0064: changed by biological action - A61M 2202/0078: changed by chemical action - A61M 2202/04: Liquids - A61M 2202/0468: non-physiological - A61M 2205/3344: Measuring or controlling pressure at the body treatment site - A61M 2210/12: Blood circulatory system - A61B: DIAGNOSIS; SURGERY; IDENTIFICATION (usefulness limited to only animals A61D) - A61L: METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES (preservation of bodies or disinfecting characterised by the agents employed A01N; preserving, e.g. sterilising, food or foodstuffs A23; preparations for medical, dental or toiletry purposes A61K) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A method and a medical elongate body are configured to prevent stagnation or turbulence of blood flow in a recess of a rugged pattern formed in a blood vessel due to bulging of a blood vessel wall at a lesion part of the blood vessel. The method involves partitioning an inside of the blood vessel into upstream and downstream sides of the recess, and introducing gel into the recess to at least partially fill the recess. A blood vessel lumen forming method and medical elongate body to form such a lumen are other aspects of the disclosure and involve introducing gel into the recess to at least partially fill the recess with the gel, and drilling the gel to remove at least some of the gel to form a passage and secure blood flow in the blood vessel. ## Claims ### Claim 1 A method for smoothening a rugged blood vessel inner wall surface at a lesion site of the blood vessel, the rugged blood vessel inner wall surface including a plurality of spaced-apart recesses in the blood vessel, the method comprising: moving a catheter in the blood vessel to position a distal portion of the catheter adjacent the rugged blood vessel inner wall surface at the lesion site; ejecting gel from the distal portion of the catheter while the distal portion of the catheter is positioned adjacent the rugged blood vessel inner wall surface to deliver the gel into the blood vessel; and filling at least one of the recesses with the gel. ### Claim 2 (depends on 1) The blood vessel lumen forming method according to claim 1, further comprising: positioning a partition within the blood vessel before ejecting the gel into the blood vessel; and stopping blood flow within the blood vessel by the partition. ### Claim 3 (depends on 2) The blood vessel lumen forming method according to claim 2, wherein the positioning of the partition within the blood vessel includes positioning the partition to stop blood flow on each of an upstream side of the at least one recess and a downstream side of the at least one recess. ### Claim 4 (depends on 2) The blood vessel lumen forming method according to claim 2, wherein the positioning of the partition within the blood vessel includes positioning the partition to stop the blood flow on the upstream side of the at least one recess before stopping the blood flow on the downstream side of the at least one recess. ### Claim 5 (depends on 1) The blood vessel lumen forming method according to claim 1, wherein the ejecting of the gel from the distal portion of the catheter includes ejecting the gel from the distal portion toward the rugged blood vessel inner wall surface and while the distal portion of the catheter is positioned at a proximal portion of the rugged blood vessel inner wall surface. ### Claim 6 (depends on 1) The blood vessel lumen forming method according to claim 1, further comprising: drilling the gel that has filled the at least one recess to remove at least some of the gel filling the at least one recess to thereby remove at least some of the gel filling the at least one recess and form a smoothened surface inside the blood vessel and secure a blood flow in the blood vessel. ### Claim 7 (depends on 6) The blood vessel lumen forming method according to claim 6, wherein the drilling of the gel also includes drilling a part of the rugged blood vessel inner wall surface to remove at least a part of the rugged blood vessel inner wall surface. ### Claim 8 (depends on 6) The blood vessel lumen forming method according to claim 6, wherein the drilling of the gel produces a lumen in the blood vessel possessing the smoothened surface, the lumen with the smoothened surface possessing an inner diameter that varies along a longitudinal extent of the blood vessel. ### Claim 9 (depends on 8) The blood vessel lumen forming method according to claim 8, further comprising: detecting both blood pressure on an upstream side of the rugged blood vessel inner wall surface and blood pressure on a downstream side of the rugged blood vessel inner wall surface to identify the side on which the blood pressure is higher; and the inner diameter of the lumen with the smoothened surface increasing toward the side on which the blood pressure is higher. ### Claim 10 (depends on 6) The blood vessel lumen forming method according to claim 6, further comprising: imaging the rugged blood vessel inner wall surface to obtain an image of the rugged blood vessel inner wall surface; and the drilling of the gel being performed based on the image obtained during the imaging. ### Claim 11 (depends on 1) The blood vessel lumen forming method according to claim 1, wherein the catheter possesses an expansion member at the distal portion of the catheter, the method further comprising: positioning the expansion member in the blood vessel so that the expansion member axially overlaps the rugged blood vessel inner wall surface; and the ejecting of the gel from the distal portion of the catheter including ejecting the gel from the expansion member so that the gel fills the at least one recess of the rugged blood vessel inner wall surface. ### Claim 12 (depends on 11) The blood vessel lumen forming method according to claim 11, further comprising: expanding the expansion member outwardly toward the rugged blood vessel inner wall surface; restricting a shape of the expansion member while being expanded toward the rugged blood vessel inner wall surface; and the ejecting of the gel from the expansion member including ejecting the gel from an outer surface of the expansion member while the shape of the expansion member is restricted so that the gel completely fills a region between the at least one recess of the rugged blood vessel inner wall surface and the outer surface of the expansion member to smoothen the rugged blood vessel inner wall surface. ### Claim 13 A medical elongate body comprising: an elongate catheter body possessing a distal end and configured to be inserted into a blood vessel starting from the distal end; an inflatable and deflatable balloon at a distal portion of the catheter body; a restricting section provided at the balloon to restrict a limit of inflation of the balloon; the balloon including a jet port portion that includes a jet port for jetting gel into a blood vessel while the balloon is positioned in the blood vessel, and the restricting section being located to restrict the limit of inflation of at least the jet port portion. ### Claim 14 (depends on 13) The medical elongate body according to claim 13, wherein the restricting section is configured to expand and contract. ### Claim 15 (depends on 13) The medical elongate body according to claim 13, wherein the restricting section is provided on an outer circumference side of the jet port portion of the balloon. ### Claim 16 (depends on 15) The medical elongate body according to claim 15, wherein the restricting section is a net body. ### Claim 17 A medical elongated body comprising: a flexible elongated body possessing a distal end and configured to be inserted into a blood vessel starting from the distal end; a jet section configured to jet gel into the blood vessel while the elongated body is positioned in the blood vessel; and a drilling unit at a distal end portion of the elongated body and configured to drill the gel jetted by the jet section in the blood vessel. ### Claim 18 (depends on 17) The medical elongated body according to claim 17, further comprising an expandable and contractable balloon in the elongated body on a proximal side with respect to the jet section. ### Claim 19 (depends on 17) The medical elongated body according to claim 17, further comprising a blood pressure detection unit configured to detect blood pressure in the blood vessel. ### Claim 20 (depends on 17) The medical elongated body according to claim 17, further comprising an imaging unit configured to image an inside of the blood vessel.