# US 2017/0280722 A1 · Compositions and methods for control of sand flies and other blood sucking insects

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- Number: US 2017/0280722 A1
- Document ID: US20170280722A1
- Status: Published application
- Kind: A1
- Application number: 15/631,967
- Filed: 2017-06-23
- Published: 2017-10-05
- Earliest claimed: 2010-04-22
- Assignees: Genesis Laboratories, Inc.
- Applicants: Genesis Laboratories, Inc.
- Inventors: Richard POCHE
- Web page: https://patentgrep.com/patent/US20170280722A1

## CPC

- A01N 51/00: Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds having the sequences of atoms O—N—S, X—O—S, N—N—S, O—N—N or O-halogen, regardless of the number of bonds each atom has and with no atom of these sequences forming part of a heterocyclic ring
- A01N 43/56: 1,2-Diazoles; Hydrogenated 1,2-diazoles
- A01N 43/68: with two or three nitrogen atoms directly attached to ring carbon atoms
- A01N 43/90: having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
- A01N 47/02: the carbon atom having no bond to a nitrogen atom
- A01N 47/34: containing the groups [IMAGE cpc-sch-A01N-0947.gif], e.g. biuret; Thio analogues thereof; Urea-aldehyde condensation products
- A23K 40/00: Shaping or working-up of animal feeding-stuffs
- A61P 33/00: Antiparasitic agents
- A61P 33/14: Ectoparasiticides, e.g. scabicides
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A23K: FODDER
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The invention relates to a new rapid release oral formulation of fipronil or imidacloprid for the effective control of blood-sucking insect populations. Embodiments of the invention relate to their use by incorporation into a feed-through formulation that can be administered orally to host animals such as birds, goats, dogs, and cattle for the rapid effective control of blood sucking insects. The formulation is fast acting and the residue of the chemicals present in the feces serves as a larvacide, effectively controlling newly hatched larvae.

## Claims

### Claim 1

An orally administered composition for controlling ectoparasites, endoparasites, and larvae thereof, in a livestock animal, wherein the composition comprises imidacloprid and at least one compound selected from the group consisting of: ivermectin, abamectin, doramectin, emamectin, and eprinomectin; wherein the livestock animal is a milk-producing animal, a meat producing animal, or a reproducing animal; wherein administration of the composition to the live stock animal improves milk production, improves meat production, or the increases the number of live births.

### Claim 2 (depends on 1)

The composition of claim 1, wherein the imidacloprid is present in an amount between 0.5% and 2% w/w.

### Claim 3 (depends on 1)

The composition of claim 1, wherein the ivermectin, abamectin, doramectin, emamectin, or eprinomectin is present in an amount between 0.001% and 0.1% w/w.

### Claim 4 (depends on 1)

The composition of claim 1, further comprising at least one additional ingredient selected from the group consisting of: vitamins, minerals, fillers, palatability enhancers, binding agents, flavors, stabilizers, emulsifiers, sweeteners, colorants, buffers, salts, and coatings.

### Claim 5 (depends on 1)

A food for livestock comprising the composition of claim 1.

### Claim 6 (depends on 5)

The food of claim 5, wherein the food is feed for an animal selected from the group consisting of: avian, simian, bovine, equine, asinine, hicrine, murine, ovine, cameline, camelid, leporine, macropodine, galline, and porcine.

### Claim 7 (depends on 1)

A kit comprising a composition for controlling ectoparasites, endoparasites, and larvae thereof, in livestock, using the composition according claim 1, wherein the orally administered composition is packaged in single application doses.

### Claim 8

A method of controlling ectoparasites, endoparasites, and larvae thereof, in a livestock animal, the method comprising administering to the livestock animal a composition comprising imidacloprid and at least one compound selected from the group consisting of: ivermectin, abamectin, doramectin, emamectin, and eprinomectin; wherein the livestock animal is a milk-producing animal, a meat producing animal, or a reproducing animal; and wherein the method improves milk production, improves meat production, or the increases the number of live births.

### Claim 9 (depends on 8)

The method of claim 8, wherein the imidacloprid is present in an amount between 0.5% and 2% w/w of composition.

### Claim 10 (depends on 8)

The method of claim 8, wherein the ivermectin, abamectin, doramectin, emamectin, or eprinomectin is present in an amount between 0.001% and 0.1% w/w

### Claim 11 (depends on 8)

The method of claim 8, wherein the composition further comprises at least one additional ingredient selected from the group consisting of: vitamins, minerals, fillers, palatability enhancers, binding agents, flavors, stabilizers, emulsifiers, sweeteners, colorants, buffers, salts, and coatings.

### Claim 12 (depends on 8)

The method of claim 8, wherein the method further reduces the spread of a vector transmitted infection in a human population living near or with the livestock animals by reducing the number of new infections in the human population.

### Claim 13 (depends on 8)

The method of claim 8, wherein the vector transmitted infection is selected from the group consisting of: malaria, dengue fever, yellow fever, chikangunya, cutaneous leishmaniasis, visceral leishmaniasis, Japanese encephalitis, West Nile, St. Louis encephalitis, LaCrosse encephalitis, Rift valley fever, and Colorado tick fever.

### Claim 14

A method of controlling ectoparasites, endoparasites, and larvae thereof, in a livestock animal, the method comprising administering to the livestock animal a composition comprising fipronil and at least one insecticide selected from the group consisting of: abamectin, doramectin, emamectin, and eprinomectin; wherein the livestock animal is a milk-producing animal, a meat producing animal, or a reproducing animal; wherein the method improves milk production, improves meat production, or the increases the number of live births.

### Claim 15 (depends on 14)

The method of claim 14, wherein the fipronil is present in an amount between 0.5% and 2% w/w of composition.

### Claim 16 (depends on 14)

The method of claim 14, wherein the abamectin, doramectin, emamectin, or eprinomectin is present in an amount between 0.001% and 0.1% w/w.

### Claim 17 (depends on 14)

The method of claim 14, wherein the composition further comprises at least one additional ingredient selected from the group consisting of: vitamins, minerals, fillers, palatability enhancers, binding agents, flavors, stabilizers, emulsifiers, sweeteners, colorants, buffers, salts, and coatings.

### Claim 18 (depends on 14)

The method of claim 14, wherein the method further reduces the spread of a vector transmitted infection in a human population living near or with the livestock animals by reducing the number of new infections in the human population.

### Claim 19 (depends on 18)

The method of claim 18, wherein the vector transmitted infection is selected from the group consisting of: malaria, dengue fever, yellow fever, chikangunya, cutaneous leishmaniasis, visceral leishmaniasis, Japanese encephalitis, West Nile, St. Louis encephalitis, LaCrosse encephalitis, Rift valley fever, and Colorado tick fever.