Factor viii glycoforms
AssigneeBayer HealthCare LLC
InventorsMyung-Sam CHO, Sham-Yuen CHAN
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Abstract
The invention concerns glycosylated proteins having human factor VIII activity. In a preferred embodiment, the protein is glycosylated with oligosaccharides that include an alpha-(2,6)-linked sialic acid and a bisecting GlcNAc linked to a core beta-mannose.
Claims3
1-46. (canceled)
A method of treating a factor VIII-associated disorder comprising administering to a human in need thereof a therapeutically effective amount of a composition comprising (1) an isolated glycosylated protein having factor VIII procoagulent activity comprising an N-linked oligosaccharide having a bisecting GlcNAc linked to a core beta-mannose and (2) a pharmaceutically acceptable adjuvant.
Dependencies are inferred from the claim text.