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OwnerJohn Christopher Anderson, Timothy Hsiau +5inventors
InventorsJohn Christopher Anderson, Timothy Hsiau, Saurabh Srivastava, Paul Ruan, Jonathan Prakash Inocencio Kotker, Rastislav Bodik, Sanjit A. Seshia
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The present disclosure provides methods for biosynthesis of acetaminophen. The present disclosure provides host cells genetically modified to provide for production of acetaminophen. The present disclosure provides a recombinant host cell that is genetically modified with one or more heterologous nucleic acids comprising nucleotide sequences encoding 4-aminobenzoate hydroxylase (4ABH) and N-hydroxyarylamine O-acetyltransferase (NhoA). The present disclosure provides a recombinant prokaryotic host cell that is genetically modified with one or more heterologous nucleic acids comprising nucleotide sequences encoding 44ABH and NhoA.
A recombinant prokaryotic host cell that is genetically modified with one or more heterologous nucleic acids comprising nucleotide sequences encoding 4-aminobenzoate hydroxylase (4ABH) and N-hydroxyarylamine O-acetyltransferase (NhoA).
A method of producing N-acetyl-p-aminophenol in an individual, the method comprising introducing into the individual one or more nucleic acids comprising nucleotide sequence encoding polypeptides comprising amino acid sequences having at least 75% amino acid sequence identity to the amino acid sequences set forth in SEQ ID NOs:1-5.
Dependencies are inferred from the claim text.