Nucleic acid constructs including a txnip promoter for the treatment of disease
AssigneeWayne State University
InventorLalit Singh Pukhrambam
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Abstract
Nucleic acids for the treatment of diseases are described. The nucleic acids include a thioredoxin-interacting protein (TXNIP) promoter and a gene that encodes a therapeutic protein or an interfering nucleic acid sequence (e.g., interfering RNA (iRNA sequence)).
Claims25
A nucleic acid construct comprising a thioredoxin-interacting protein (TXNIP) promoter operably linked to a gene encoding (i) a therapeutic protein selected from (a) insulin, an insulin-like protein, or an insulin-promoting protein, (b) a neurotrophic factor selected from brain-derived neurotrophic factor (BDNF) or glia-derived neurotrophic factor (GDNF);
- or (c) a therapeutic protein that reduces cellular oxidative stress, inflammation and/or apoptosis;
- and/or (ii) an interfering nucleic acid sequence that targets expression of a protein that promotes cellular oxidative stress, inflammation and/or apoptosis.
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