Non-Bioconvertible C3-Substituted Pregnenolone Derivatives for Use in the Treatment of Treatment-Resistant Depression
AssigneeMapreg
InventorsMassimiliano BIANCHI, Etienne BAULIEU, Isabelle VILLEY
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Abstract
The present invention relates to methods for the treatment of treatment-resistant depression (TRD), comprising the administration of compounds of formula (I), which are blocked in C3 position and cannot metabolize in vivo into pregnenolone derivatives and which do not have significant affinity for steroid hormonal receptors and for all tested classical main receptors and receptors of neurotransmitters of the central nervous system.
Claims18
A method for treating treatment-resistant depression (TRD) in a subject in need thereof, comprising administering to said patient a therapeutically efficient amount of a compound of formula (I):
- wherein:
- wherein:
- independently represents a single or a double bond;
- R1 represents a C1-C4 alkyl;
- R2 represents —CO—;
- —CH(OH)— or —CH(O—COCH3)—;
- and
- R3 represents H or CHCl2 and R4 represents H or CH3, or R3 and R4 together represent
- or a pharmaceutically acceptable salt thereof.
A method for treating treatment-resistant depression (TRD) in a subject in need thereof, comprising administering to said patient a therapeutically efficient amount of 3β-methoxy-pregna-5α-ene-20α-one of formula:
- or pharmaceutically acceptable salts thereof.
Dependencies are inferred from the claim text.