Method, system and apparatus for quantitative surgical image registration

A method of image registration, comprising:

• prior to a surgical procedure, obtaining a preoperative image of patient issue at a computing device using a first imaging modality;
• using the first imaging modality, obtaining a first plurality of preoperative measurements of a material property of the patient tissue at the computing device, each measurement of the first plurality of preoperative measurements corresponding to a respective point in the preoperative image;
• storing the preoperative image and the preoperative measurements in a memory of the computing device;
• during the surgical procedure, obtaining an intraoperative image of the patient tissue at the computing device using a second imaging modality;
• using the second imaging modality, obtaining a second plurality of intraoperative measurements of the material property of the patient tissue at the computing device, each measurement of the second plurality of intraoperative measurements corresponding to a respective point in the intraoperative image;
• comparing the first and second pluralities of measurements at the computing device to determine a transformation for registering the preoperative image and the intraoperative image;
• storing the transformation in the memory in association with one of the intraoperative image and the preoperative image;
• applying the transformation to the intraoperative image;
• and
• controlling a display connected to the computing device to present the preoperative image overlaid with the intraoperative image.