Cross platform transformation of gene expression data
AssigneeKoninklijke Philips N.V.
InventorsYEE HIM CHEUNG, WILHELMUS FRANCISCUS JOHANNES VERHAEGH, NEVENKA DIMITROVA
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Abstract
Data-driven generalized regression-based frameworks that support the transformation of measurements, applicable but not limited to gene expressions, from one platform to another over a wide dynamic range, with selected summary statistics/feature values as predictors for the model parameters. The framework consists of primary model training and transformation, and additional levels of categorical regression and transformation processes.
Claims22
A method for transforming gene expression data, the method comprising:
- constructing a primary model utilizing sample expression data for transforming gene expression data from a first profiling platform to a second profiling platform.
An apparatus for transforming gene expression data, the apparatus comprising:
- a processor;
- an interface;
- and
- computer executable instructions operative on said processor for:
- constructing a primary model utilizing sample expression data for transforming gene expression data from a first profiling platform to a second profiling platform such that the overall distribution of the transformed data resembles that of the second platform.
Dependencies are inferred from the claim text.