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US 2017/0248618 A1Published application
Hemolysis detection device, system and method
AssigneeSiemens Healthcare Diagnostics Inc.
InventorsAndrew John Baxter, Paul William Cotton
Life of this patent
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Abstract
Aspects of the present invention are directed to devices, systems and methods that enable the quick and reliable detection of hemolysis in a sample such that a sample which exhibits an unacceptable level of hemolysis can be flagged or disregarded in an associated diagnostic test.
Claims20
A diagnostic system comprising:
- a device comprising a plasma separation membrane configured to separate a plasma fraction from a first blood sample by flow of the plasma fraction through the plasma separation membrane, wherein the plasma fraction comprises plasma and an amount of hemoglobin upon the occurrence of hemolysis in the first sample;
- a detection system configured for receipt of the device thereon or therein and for determining the amount of hemoglobin in the plasma fraction, and
- a diagnostic instrument in communication with the detection system configured for analyzing a second blood sample for one or more analytes,
- wherein the device comprises:
- a body with an upper portion and a lower portion;
- an opening defined in the body for introduction of the first blood sample;
- and
- a second membrane positioned below the plasma separation membrane so as to receive the plasma fraction from the plasma separation membrane,
- wherein the device further comprises a slit in the lower portion of the body defining a pathway for energy to be applied to the second membrane from the detection system.
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A method for detecting hemolysis in a whole blood sample comprising:
- contacting a first blood sample with a plasma separation membrane to separate a plasma fraction from the whole blood sample, the plasma fraction comprising plasma and an amount of hemoglobin therein upon hemolysis of the sample.
- determining an amount of hemoglobin in the plasma fraction with a detection system, wherein the determining is done by a spectroscopy;
- and
- analyzing a second sample from at least a same source as the first blood sample for an analyte in a diagnostic instrument in communication with the detection system.
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Dependencies are inferred from the claim text.