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US 2017/0248585 A1Published application
Therapeutic antibodies against ror-1 protein and methods for use of same
AssigneeThe Regents of the University of California
InventorsThomas J. Kipps, George F. Widhopf, II, Bing Cui
Life of this patent
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Abstract
Therapeutic antibodies having binding specificity for ROR-1 expressed on cancer cells (particularly leukemic and lymphomic cells) and pharmaceutical compositions containing one or more such antibodies for use in treating cancer. Methods for diagnosing such cancers through in vitro detection of binding to ROR-1 protein expressed on putative cancer cells are also provided.
Claims12
-27. (canceled)
A method of identifying an anti-ROR1 antibody, the method comprising:
- (i) contacting an antibody with a first ROR1 polypeptide comprising a glutamic acid residue at a position corresponding to position 138 of SEQ ID NO:36;
- (ii) detecting said antibody binding to said first ROR1 polypeptide;
- (iii) contacting said antibody with a second ROR 1 polypeptide not comprising a glutamic acid residue at a position corresponding to position 138 of SEQ ID NO:36;
- and
- (iv) detecting said antibody not binding to said second ROR1 polypeptide, thereby identifying an anti-ROR1 antibody.
2 more elements
Dependencies are inferred from the claim text.