Biomarkers for diagnosis of lung diseases and methods of use thereof
AssigneeVeracyte, Inc.
InventorsJonathan I. WILDE, Sharlene VELICHKO, Catalin BARBACIORU, James DIGGANS, Giulia KENNEDY
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Abstract
The present disclosure provides methods for diagnosis of interstitial lung diseases (ILDs). The present disclosure provides methods for differential diagnosis of idiopathic pulmonary fibrosis from other ILDs. Compositions and kits useful in carrying out a subject method are also provided.
Claims25
A method for evaluating a lung tissue, the method comprising:
- a) determining an expression level of a gene product of a gene set forth in any of FIGS. 6A-27E, or in Table 3 or 4 in a lung tissue sample obtained from a patient, generating an expression level value;
- and
- b) classifying the lung tissue sample as an interstitial lung disease (ILD) tissue sample by comparing the expression level value to a reference expression level value.
A method of diagnosing an interstitial lung disease (ILD) in a patient, the method comprising:
- a) determining an expression level of a gene product of a gene set forth in any one of FIGS. 6A-27E, or in Table 3 or 4 in a lung tissue sample obtained from a patient suspected of having an ILD;
- and
- b) providing a diagnosis of an ILD based on comparison of the expression level value to a reference expression level value.
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A method of diagnosing idiopathic pulmonary fibrosis (IPF) in a patient, the method comprising:
- a) assaying, in a tissue sample obtained from a patient suspected of having an interstitial lung disease, an expression level of a gene product of a gene set forth in any one of FIGS. 9A-9D, 10A-10G, 19A-22C, or Table 4, generating an expression level value;
- b) identifying the patient as having IPF when the expression level value differs significantly from a reference expression level value.
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Dependencies are inferred from the claim text.