Nucleic acid capable of inhibiting expression of beta-2gpi
AssigneeKyowa Hakko Kirin Co., Ltd.
InventorsYoji YAMADA, Hiroto IWAI, Kazuhiro MASUDA, Minako KANDA
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Abstract
The present invention provides a nucleic acid having activity to suppress expression of β2GPI, a pharmaceutical composition comprising the nucleic acid, and a prophylactic or therapeutic drug containing the nucleic acid for autoimmune diseases such as APS, SLE and the like and thrombosis in hemodialysis.
Claims10
A double-stranded nucleic acid that decreases expression of β32GPI gene, which consists of a sense strand and an antisense strand, and comprises a double-stranded region of at least 11 base pairs, wherein an oligonucleotide chain having a chain length of at least 17 nucleotides and nucleotides at most in the aforementioned antisense strand is complementary to a target β32GPI mRNA sequence shown in SEQ ID NO:
- 2459.
Dependencies are inferred from the claim text.