Interfering rna molecules
AssigneeSilence Therapeutics GmbH
InventorsKlaus GIESE, Jörg KAUFMANN, Anke KLIPPEL-GIESE
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Abstract
The present invention is related to a ribonucleic acid comprising a double stranded structure whereby the double-stranded structure comprises a first strand and a second strand, whereby the first strand comprises a first stretch of contiguous nucleotides and whereby said first stretch is at least partially complementary to a target nucleic acid, and the second strand comprises a second stretch of contiguous nucleotides whereby said second stretch is at least partially identical to a target nucleic acid, and whereby the double stranded structure is blunt ended.
Claims24
A double-stranded siRNA molecule against a target nucleic acid, wherein the double-stranded siRNA molecule comprises a first strand and a second strand,
- wherein the first strand comprises a first stretch that is complementary to the target nucleic acid,
- wherein the second strand comprises a second stretch that is complementary to the first stretch,
- wherein the first strand and the second strand form a double-stranded structure comprising the first stretch and the second stretch,
- wherein the double-stranded siRNA molecule is blunt ended on at least one end, and wherein each stretch consists of at least 15 and fewer than 30 ribonucleotides and wherein the first stretch and the second stretch each comprises contiguous alternating modified ribonucleotides, wherein the alternating modified ribonucleotides alternate with unmodified or differently modified ribonucleotides.
Dependencies are inferred from the claim text.