Combinatorial treatment of chemotherapy and armed viruses targeting tumor
AssigneesYissum Research Development Company of the Hebrew University of Jerusalem, Hadasit Medical Research Services and Development Ltd.
InventorsAlik HONIGMAN, Shahar FRENKEL, David SHNEOR
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Abstract
Methods, and kits for inducing cell death in proliferating cells as well as methods of treating cancer, are provided. In some embodiments, the methods comprise administering a composition comprising a replication competent retrovirus (RCR) comprising an antisense molecule that targets a hypoxia-inducible gene including but not limited to HIF-1 and CREB, and anti-cancer therapy.
Claims20
A method of inducing cell death in a proliferating cell, the method comprising:
- a. contacting said cell with a replication competent retrovirus (RCR) comprising one or more antisense molecules that target at least one hypoxia-inducible gene selected from the group consisting of:
- HIF-1 and CREB, and
- b. exposing said cell to an anti-cancer therapy,
- thereby inducing cell death in a proliferating cell.
A method of treating, or ameliorating cancer in a subject in need thereof, the method comprising:
- a. administering to said subject a replication competent retrovirus (RCR) comprising one or more antisense molecules that target at least one hypoxia-inducible gene selected from the group consisting of:
- HIF-1 and CREB, and
- b. administering to said subject an anti-cancer therapy,
- thereby treating or ameliorating cancer in a subject in need thereof.
A kit comprising at least one agents selected from the group consisting of:
- a. a replication competent retrovirus (RCR) comprising at least one antisense molecule that targets a hypoxia-inducible gene selected from the group consisting of:
- HIF-1 and CREB, the RCR being adapted or identified for co-administration with an anti-cancer agent;
- and
- b. an anti-cancer agent, adapted or identified for co-administration with an RCR.
Dependencies are inferred from the claim text.