Coagulation factor ix compositions and methods of making and using same
AssigneeAmunix Operating Inc.
InventorsVolker SCHELLENBERGER, Willem P. Stemmer, Nathan C. Geething, Wayne To, Joshua Silverman, Chia-wei Wang, Benjamin Spink
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Abstract
The present invention relates to compositions comprising factor IX coagulation factors linked to extended recombinant polypeptide (XTEN), isolated nucleic acids encoding the compositions and vectors and host cells containing the same, and methods of making and using such compositions in treatment of coagulation factor-related diseases, disorders, and conditions.
Claims21
A factor IX fusion protein comprising a factor IX polypeptide and an extended recombinant polypeptide (XTEN), wherein the XTEN comprises an amino acid sequence having at least 90% identity to the amino acid sequence set forth in SEQ ID NO:
- 36, 37, 38, or any combination thereof.
3-18. (canceled)
Dependencies are inferred from the claim text.