Human-derived anti-dipeptide repeats (dprs) antibody
AssigneeNeurimmune Holding AG
InventorsFabio MONTRASIO, Jan GRIMM
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Abstract
Provided are novel human-derived dipeptide repeat (DPR) specific antibodies as well as synthetic variants and biotechnological derivatives thereof, preferably capable of binding C9ORF72 DPRs, as well as methods related thereto. Assays, kits, and solid supports related to antibodies specific for DPRs and DPR proteins such C9ORF72 DPRs are also disclosed. The antibody of the present invention can be used in pharmaceutical and diagnostic compositions for DPR protein-targeted immunotherapy and diagnostics.
Claims48
A human-derived monoclonal anti-dipeptide (XX′) repeat (DPR) antibody, or a DPR-binding fragment, synthetic variant or biotechnological derivative thereof, which recognize at least one DPR as translated from the chromosome 9 open reading frame 72 (C9orf72) gene in its antisense direction (poly-(Pro-Arg;
- PR), poly-(Pro-Ala;
- PA), poly-(Gly-Pro;
- GP)) and/or at least one DPR as translated from the C9orf72 gene in its sense direction (poly-(Gly-Arg;
- GR), poly-(Gly-Ala;
- GA), poly-(Gly-Pro;
- GP)), preferably wherein the repeat number is (XX′)15.
Use of the cDNA of claim 27, the vector of claim 28, or the host cell of claim 30 for the production of an anti-DPR antibody.
The antibody of claim 34, wherein the detectable label is selected from the group consisting of an enzyme, a radioisotope, a fluorophore, and a heavy metal.
Dependencies are inferred from the claim text.