ANTI-IL-1beta ANTIBODIES AND METHODS OF USE
AssigneeHoffmann-La Roche Inc.
InventorsStefan Dengl, Peter Michael Huelsmann, Christian Gassner, Sebastian Breuer, Olaf Mundigl, Guy Georges, Ralf Schumacher, Guido Hartmann, Sabine Gruener
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Abstract
Herein are reported humanized anti-IL-1beta antibodies that are humanized variants of the murine anti-IL-1beta antibody H34. A specific humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 27, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 28.
Claims14
A humanized antibody that specifically binds to human and cynomolgus IL-1beta, wherein the humanized antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 25, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 26, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 28, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 15, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 16, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 17.
Dependencies are inferred from the claim text.