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US 2017/0247440 A1Published application
Anti-pdgf-b antibodies and methods of use
AssigneeHoffmann-La Roche Inc.
InventorsMarc Bedoucha, Sebastian Breuer, Stefan Dengl, Christian Gassner, Guy Georges, Sabine Gruener, Guido Hartmann, Peter Michael Huelsmann, Joerg Moelleken, Olaf Mundigl, Joerg Thomas Regula, Barbara Weiser
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Abstract
Herein are reported anti-PDGF-B antibodies and their use in ophthalmology.
Claims20
An antibody that specifically binds to human PDGF-B, wherein the antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 93, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 94, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 96, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 98, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 99, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 100.
3 more elements
An antibody that specifically binds to human PDGF-B, wherein the antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO:
- 102, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO:
- 103, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO:
- 105, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO:
- 107, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO:
- 108, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO:
- 109.
3 more elements
Dependencies are inferred from the claim text.