Methods for treating osteogenesis imperfecta
AssigneesGenzyme Corporation, Baylor College of Medicine
InventorsBrendan Lee, Kuber T. Sampath
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Abstract
The present invention provides methods for treating and improving the symptoms of osteogenesis imperfecta (OI) in a subject by administering to the subject a therapeutically effective amount of a binding agent that binds to transforming growth factor beta (TGFβ).
Claims24
A method for treating osteogenesis imperfecta (OI) in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antibody or an antigen binding fragment thereof that specifically binds to transforming growth factor beta (TGFβ).
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A method for treating osteogenesis imperfecta (OI) in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antibody or an antigen binding fragment thereof that binds to transforming growth factor beta (TGFβ), wherein the antibody comprises a heavy chain comprising the amino acid sequence of SEQ ID NO:
- 14, and a light chain comprising the amino acid sequence of SEQ ID NO:
- 15.
A method for treating osteogenesis imperfecta (OI) in a subject in need thereof comprising administering to the subject a therapeutically effective amount of an antibody or an antigen binding fragment thereof that binds to transforming growth factor beta (TGFβ) in combination with at least one therapeutic agent.
Dependencies are inferred from the claim text.