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US 2017/0247429 A1Published application
Blood-brain barrier disrupting agents and uses thereof
AssigneesTel HaShomer Medical Research Infrastructure and Services Ltd., Yeda Research and Development Co. Ltd.
InventorsItzik Cooper, David Guez, David Last, Yoram Shechter, Matityahu Fridkin, Yael Mardor
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Abstract
The present invention relates to blood-brain barrier disrupting agents containing a modified serum albumin comprising serum albumin. The present invention further relates to pharmaceutical compositions comprising said agents and use thereof for the treatment of brain diseases and disorders.
Claims21
1-28. (canceled)
A modified serum albumin, comprising:
- serum albumin, or an analogue thereof, having a plurality of neutralized amino acid side chain residues selected from the group consisting of Aspartic acid side chain residue, Glutamic acid side chain residue, and a combination thereof;
- wherein each of said plurality of neutralized amino acid side chain residues is covalently attached to a capping moiety.
A pharmaceutical composition, comprising:
- a cationized serum albumin or an analogue thereof, said cationized serum albumin includes a plurality of cationized amino acid side chain residues selected from the group consisting of Aspartic acid side chain residue, Glutamic acid side chain residue, and a combination thereof;
- and
- pharmaceutically acceptable diluents or carriers.
Dependencies are inferred from the claim text.