Chimeric Antigen Receptors
AssigneeMolMed SpA
InventorsAttilio Bondanza, Monica Casucci, Maria Chiara Bonni
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Abstract
A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
Claims30
A chimeric antigen receptor (CAR) comprising an extracellular spacer which comprises at least part of the extracellular domain of human low affinity nerve growth factor (LNGFR) or a derivative thereof.
A CAR according to any preceding claim wherein the extracellular spacer comprises the first three TNFR-Cys domains of LNGFR or fragments or derivatives thereof.
A CAR according to any preceding claim wherein the spacer comprises the fourth TNFR-Cys domain (TNFR-Cys 4) but wherein the following amino acid sequence is removed from said domain:
- NHVDPCLPCTVCEDTERQLRECTRW and replaced with the following amino acid sequence:
- ARA.
A CAR according to any preceding claim wherein the spacer comprises the serine/threonine-rich stalk of LNGFR.
Dependencies are inferred from the claim text.