Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies
AssigneesMor Research Applications Ltd., Rappaport Family Institute for Research in the Medical Sciences
InventorsMichal A. RAHAT, Nitza LAHAT, Miriam WALTER, Haim BITTERMAN
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Abstract
Isolated peptides from the protein EMMPRIN (CD147/Basigin) and antibodies directed against antigenic determinants within the peptides. Pharmaceutical compositions including the peptides and antibodies and methods of their production and use in vaccination, immunotherapy and diagnosis of proliferative, hyperpermeability, inflammatory, and angiogenesis-related diseases and disorders.
Claims12
-23. (canceled)
An antibody or an antibody fragment thereof comprising at least an antigen-binding portion, wherein said antibody or said antibody fragment thereof recognizes an epitope of the protein EMMPRIN within a sequence set forth in Formula I:
- X5GHRWX1X2GGX3VLX4 (Formula I),
- wherein X1 is selected from Met and Leu, X2 is selected from Arg and Lys, X3 is selected from Lys and Val, X4 is Cys, Lys or represents the peptide's C-terminal selected from carboxy acid, amide or alcohol group, and X5 is Cys, Lys or represents the peptide's N-terminal.
Dependencies are inferred from the claim text.