Ebolavirus pre-hairpin intermediate mimics and methods of use
AssigneesUniversity of Utah Research Foundation, Navigen, Inc., The United States of America—Air Force
InventorsTracy R. CLINTON, Michael Thomas JACOBSEN, Matthew T. WEINSTOCK, Brett D. WELCH, Debra Muir ECKERT, Michael S. KAY
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Abstract
Ebolavirus is a highly lethal filovirus that causes hemorrhagic fever in humans and non-human primates. With no approved treatments or preventatives, the development of an anti-ebolavirus therapy to protect against natural infections and potential weaponization is an urgent unmet global health need. The design, biophysical characterization, and validation of peptide mimics of the ebolavirus N-trimer (“N-trimer mimics”) are described herein.
Claims21
An Ebolavirus N-trimer mimic comprising a trimer of peptide monomers, wherein each peptide monomer comprises an Ebolavirus glycoprotein 2 (GP2) N-peptide sequence or a portion thereof and at least one soluble trimeric coiled-coil peptide.
Dependencies are inferred from the claim text.