Anti-microbial peptides
AssigneeTensive Controls, Inc.
InventorKenneth Allen GRUBER
Life of this patent
Estimating the term…
Abstract
Described herein are anti-microbial peptides having enhanced activity and transport.
Claims144
A non-naturally occuring anti-microbial peptide comprising at least three or more amino acid or amino acid analog residues, wherein at least one of the three or more residues comprises:
- (a) at least one or more natural, synthetic, or chemically modified cationic amino acid residues;
- (b) at least one, synthetic, or chemically modified anionic amino acid residue;
- (c) at least one or more natural, synthetic, or chemically modified aromatic residues;
- or
- (d) a combination of natural, synthetic, or chemically modified amino acid residues thereof.
The non-naturally occuring anti-microbial peptide of anyone of claims 1-19, wherein an anti-biofilm peptide is covalently linked to the anti-microbial peptide.
A non-naturally occurring anti-microbial peptide comprising the sequence according to Formula I:
- X1-X2-X3-R1-R2-[R3-R4-R5-R6-R7-R8-R9-R10-R11-R12-R13-R14-R15-R16-R17]Y1-Y2-Y3,
- wherein:
- X1, X2, and X3 represent optional N-terminal residues;
- R1 to R7 represent residues of the anti-microbial peptide;
- Y1, Y2, and Y3 represent optional degradation-resistant C-terminal residues.
The non-naturally occuring anti-microbial peptide of any one of claims 38-54, wherein the non-naturally occuring anti-microbial peptide is cyclized.
A non-naturally occurring anti-microbial peptide comprising the sequence according to Formula I:
- X1 R1 R2 [R3 R4 R5 R6 R7 R8 R9 R10 R11 R12 R13 R14 R15 R16 R17]Y1 Y2, wherein:
- X1 is norleucine and Y1 Y2 is D-Pro-D-Val, D-Val-D-Pro, D-Phe-D-Val or D-Val-D-Phe, wherein R1 to R17 represent residues of the anti-microbial peptide and R1 to R17 is further represented by formula II:
- P0-2−|−[N−|−(U)0-1−|−(P|A)1-3−|−(U)0-1−|−(P|A)0-3−|−(U)0-1−|−(P|A)0-3−|−(U)0-1−|−(P|A)0-3−P],
- wherein:
- “N” is aspartic acid;
- “U” glutamine or leucine;
- “P” is proline, histidine, lysine, or arginine;
- “A” is noralanine, 2′-naphthylalanine, tryptophan, tyrosine, or phenylalanine;
- and
- wherein an anti-biofilm peptide is optionally covalently attached to the N-terminus of the antimicrobial peptide of formula I and formula II.
A non-naturally occuring anti-microbial peptide comprising any one of SEQ NOs:
- 1-4296.
Dependencies are inferred from the claim text.