Novel compounds
AssigneeMission Therapeutics Limited
InventorsAlison Jones, Mark Ian Kemp, Martin Lee Stockley, Karl Richard Gibson, Gavin Alistair Whitlock, Andrew Madin
Life of this patent
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Abstract
The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase L1 (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.
Claims17
A compound having the formula (I)
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 represents a 5 to 10 membered heteroaryl ring which may be optionally substituted;
- R2, R3, R4, R5, R6 and R8 each independently represent a hydrogen atom, cyano, an optionally substituted C1-C3 alkyl, an optionally substituted C1-C3 alkoxy group, one or more spirocyclic groups where R3 is linked to R4, R5 is linked to R6 or R8 is linked to R7, or R2 is linked to R8 to form an optionally substituted C3-C4 cycloalkyl ring, R6 is linked to R7 to form an optionally substituted C3-C4 cycloalkyl ring;
- and
- R7 represents a hydrogen atom, a fluorine atom, cyano, an optionally substituted C1-C3 alkyl, an optionally substituted C1-C3 alkoxy group or an optionally substituted aryl or heteroaryl ring or is linked to R8 to form a spirocyclic group or is linked to R6 to form an optionally substituted C3-C4 cycloalkyl ring.
A compound according to formula (II)
- or a pharmaceutically acceptable salt thereof, wherein:
- R1 represents a 5 to 10 membered heteroaryl ring which may be optionally substituted;
- R2, R3, R4, R5, R6 and R8 each independently represent a hydrogen atom, cyano, an optionally substituted C1-C3 alkyl, an optionally substituted C1-C3 alkoxy group, one or more spirocyclic groups where R3 is linked to R4, R5 is linked to R6 or R8 is linked to R7, or R2 is linked to R8 to form an optionally substituted C3-C4 cycloalkyl ring, or R6 is linked to R7 to form an optionally substituted C3-C4 cycloalkyl ring;
- and
- R7 represents a hydrogen atom, a fluorine atom, cyano, an optionally substituted C1-C3 alkyl, an optionally substituted C1-C3 alkoxy group or an optionally substituted aryl or heteroaryl ring or is linked to R8 to form a spirocyclic group or is linked to R6 to form an optionally substituted C3-C4 cycloalkyl ring.
(canceled)
Dependencies are inferred from the claim text.