Process for the preparation of canagliflozin
AssigneeMylan Laboratories Limited
InventorsSiva Ram Prasad Vellanki, Raja Babu Balusu, Ramakrishna Pilli, Rajeswara Roa Jawaji, Ankama Nayudu Annadasu
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Abstract
A process for the preparation of canagliflozin. The process may be effectively implemented on an industrial scale. Several compounds useful as intermediates for the synthesis of canagliflozin (Formula 4, Formula 4a, Formula 4b and Formula 5) are also disclosed. The process involves the reduction of the compound of formula 3 in the presence of a metal hydride and an organic solvent to obtain the compound of formula 4, converting this into a compound of formula 5 which in turn is converted into canagliflozin.
Claims34
A process for the preparation of canagliflozin, comprising the steps of:
- a. reducing formula 3 in the presence of a metal hydride and an organic solvent to obtain formula 4;
- b. converting formula 4 to formula 5 ;
- and
- c. converting formula 5 to canagliflozin.
A compound of formula 4:
A compound of formula 4a:
- wherein “Pg” is organosilicon-based, acetyl, tosyl, or methyl group.
A compound of formula 4b:
- wherein “Pg” is organosilicon-based, acetyl, tosyl, or methyl group.
A compound of formula 5:
Dependencies are inferred from the claim text.