Inhibitors of Low Molecular Weight Protein Tyrosine Phosphatase and Uses Thereof

A compound having the formula:

• or a pharmaceutically acceptable salt thereof, wherein
• Z is independently a covalent bond, —O—, —NR9—, —NR9C(O)—, —C(O)NR9—, —O—C(O)—, or —C(O)—O—,
• L1 is independently a bond, substituted or unsubstituted alkylene, substituted or unsubstituted heteroalkylene, substituted or unsubstituted cycloalkylene, substituted or unsubstituted heterocycloalkylene, substituted or unsubstituted arylene, or substituted or unsubstituted heteroarylene;
• R1 is independently hydrogen, —NR10R11, —OR12, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R2 is independently hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R3 is independently hydrogen, halogen, —CX33, —CHX32, —CH2X3, —OCX33, —OCHX32, —OCH2X3, —CN, —SOn3R16, —SOv3NR13R14, —NHC(O)NR13R14, —N(O)m3, —NR13R14, —C(O)R15, —C(O)—OR15, —C(O)NR13R14, —OR16, —NR13SO2R16, —NR13C(O)R15, —NR13C(O)OR15, —NR13OR15, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R4 is independently hydrogen, halogen, —CX43, —CHX42, —CH2X4, —OCX43, —OCHX42, —OCH2X4, —CN, —SOn4R20, —SOv4NR17R18, —NHC(O)NR17R18, —N(O)m4, —NR17R18, —C(O)R19, —C(O)—OR19, —C(O)NR17R18, —OR20, —NR17SO2R20, —NR17C(O)R19, —NR17C(O)OR19, —NR17OR19, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R5 is independently hydrogen, halogen, —CX53, —CHX52, —CH2X5, —OCX53, —OCHX52, —OCH2X5, —CN, —SOn5R24, —SOv5NR21R22, —NHC(O)NR21R22, —N(O)m5, —NR21R22, —C(O)R23, —C(O)—OR23, —C(O)NR21R22, —OR24, —NR21SO2R24, —NR21C(O)R23, —NR21C(O)OR23, —NR21OR23, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 is independently hydrogen, halogen, —CX63, —CHX62, —CH2X6, —OCX63, —OCHX62, —OCH2X6, —CN, —SOn6R28, —SOv6NR25R26, —NHC(O)NR25R26, —N(O)m6, —NR25R26, —C(O)R27, —C(O)—OR27, —C(O)NR25R26, —OR28, —NR25SO2R28, —NR25C(O)R27, —NR25C(O)OR27, —NR25OR27, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• each R7, R8, R9, R10, R11, R12, R13, R14, R15, R16, R17, R18, R19, R20, R21, R22, R23, R24, R25, R26, R27, and R28 is independently hydrogen, —CX3, —CN, —COOH, —CONH2, —CHX2, —CH2X, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocycloalkyl, substituted or unsubstituted aryl, or substituted or unsubstituted heteroaryl;
• R6 and R7, R10 and R11, R14 and R15, and R18 and R19 substituents bonded to the same nitrogen atom may optionally be joined to form a substituted or unsubstituted heterocycloalkyl or substituted or unsubstituted heteroaryl;
• each X3, X4, X5, and X6 is independently —F, —Cl, —Br, or —I;
• each m3, m4, m5, and m6 is independently 1 or 2;
• each n3, n4, n5, and n6 is independently an integer from 0 to 3;
• each v3, v4, v5, and v6 is independently 1 or 2;
• and
• when R3-R6 are each H, and —Z-L1-R2 is —NH(CH2)2N(CH2)5 or —N(CH2)5, then R1 is not unsubstituted phenyl.