PROCESS FOR PREPARING (CYCLOPENTYL[d]PYRIMIDIN-4-YL)PIPERAZINE COMPOUNDS

A process for preparing a compound of Formula IX:

• or a salt thereof, wherein R2 is hydrogen or an amino protecting group, the process comprising:
• (i) contacting a compound of Formula III,
• or a salt thereof, wherein R1 is hydrogen or an amino protecting group, with a metalating agent to form a compound of Formula I:
• or salt thereof;
• (ii) reducing the compound of Formula I, or a salt thereof, to form a compound of Formula VIIa:
• or salt thereof;
• (iii) optionally deprotecting the compound of Formula VIIa, or salt thereof, to form a compound of Formula VIIb:
• or salt thereof;
• and
• (iv) contacting the compound of Formula VIIb, or salt thereof, with a compound of Formula VIII:
• or salt thereof, to form the compound of Formula IX, or salt thereof.