Fluorinated pyridazin-3-ones for the use thereof in the treatment of lung diseases
AssigneesUniversite De Reims Champagne-Ardenne, Inserm (Institut National De La Sante Et De La Recherche Medicale), Universite De Rouen
InventorsStephane GERARD, Jean-Philippe BOUILLON, Azzaq BELAAOUAJ, Eric HENON
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Abstract
The present invention concerns compounds belonging to the family of fluorinated pyridazin-3-ones, for the use thereof in the treatment of broncho-pulmonary conditions. In compounds having a formula, or a pharmaceutically acceptable salt of the compound, the formula includes R1 representing H, an alkyl, an aryl or a heteroaryl; either E2 and E3 representing, separately from each other, H, an alkyl, an aryl or a heteroaryl, or R2 and R3 being bridged within a same cycle or via several cycles; and F representing CF3, (CF2)nCF3 or CF2H, with n representing an integer of between 1 and 7.
Claims9
A compound being in a family of fluorinated pyridazin-3-ones, for treatment of broncho-pulmonary diseases, said compound, or one of its pharmaceutically acceptable salts, comprising a chemical composition having the following formula (I):
- wherein:
- R1 represents H, and alkyl, an aryl or a heteroaryl,
- R2 and R3 represent either independently of each other, an H, an alkyl, an aryl or a heteroaryl, or R2 and R3 are bridged within a same ring or via several rings;
- R5 represents CF3, (CF2)nCF3 or CF2H with “n” representing an integer comprised between 1 and 7.
Dependencies are inferred from the claim text.