Quinolinone compound and use thereof

A compound having Formula (I) or a stereoisomer, a geometric isomer, a tautomer, an N-oxide, a hydrate, a solvate, a metabolite, an ester, a pharmaceutically acceptable salt or a prodrug thereof,

• wherein,
• R1 is H or C1-4 alkyl, and wherein C1-4 alkyl is optionally substituted with one, two, three or four substituents independently selected from oxo (═O), halogen, amino, hydroxy, mercapto, cyano, C1-4 alkyl, C2-4 alkenyl, C1-4 haloalkyl, C1-4 alkoxy, acyl, sulfonyl, C3-6 cycloalkyl, C2-5 heterocyclyl or C1-5 heteroaryl;
• each of R2, R3, R4 and R5 is independently H or -L-R10, with the proviso that R2, R3, R4 and R5 are not H at the same time;
• wherein each L is independently —(CR11R12)m—, —(CR11R12)p—O—, —(CR11R12)p—S(═O)n—, —(CR11R12)p—N(R13)—, —(CR11R12)p—C(═X)—, —(CR11R12)p—C(═X)N(R13)—(CR11R12)q—, —(CR11R12)p—C(═X)O—(CR11R12)q—, —(CR11R12)p—OC(═X)N(R13)—(CR11R12)q—, —(CR11R12)p—N(R13)C(═X)N(R13)—(CR11R12)q—, —(CR11R12)p—S(═O)2N(R13)—(CR11R12)q—, —(CR11R12)p—S(O)2O—(CR11R12)q—, C3-10 cycloalkylene, C2-9 heterocyclylene or C1-9 heteroarylene, and wherein optionally each of C3-10 cycloalkylene, C2-9 hererocyclylene and C1-9 heteroarylene is independently substituted with one, two, three or four substituents independently selected from oxo (═O), hydroxy, mercapto, amino, nitro, cyano, halogen, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, acyl, sulfonyl, C3-10 cycloalkyl, C2-9 heterocyclyl, C6-10 aryl or C1-9 hereroaryl;
• wherein each X is independently O or S;
• each R11 and R12 is independently H, halogen, cyano, hydroxy, mercapto, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-10 cycloalkyl, C2-9 heterocyclyl, C6-10 aryl or C1-9 heteroaryl, and wherein optionally each of hydroxy, mercapto, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, C3-10 cycloalkyl, C2-9 heterocyclyl, C6-10 aryl and C1-9 heteroaryl is independently substituted with one, two, three or four substituents independently selected from oxo (═O), halogen, hydroxy, amino, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, acyl, sulfonyl, C3-8 cycloalkyl, C2-7 heterocyclyl, C6-19 aryl or C1-9 heteroaryl;
• each R13 is independently H, C1-6 alkyl, C3-19 cycloalkyl, C2-9 heterocyclyl, C6-19 aryl or C1-9 heteroaryl, and wherein optionally each of C1-6 alkyl, C3-19 cycloalkyl, C2-9 heterocyclyl, C6-19 aryl and C1-9 heteroaryl is independently substituted with one, two, three or four substituents independently selected from oxo (═O), cyano, nitro, halogen, hydroxy, amino, mercapto, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, acyl, sulfonyl, C3-8 cycloalkyl, C2-7 heterocyclyl, C6-16 aryl or C1-9 heteroaryl;
• each R10 is independently —OR14, —NR15R16, —C(═O)NR15R16, —N(R15)C(═O)R17, —C(═O)R17, —S(═O)nR18, —S(═O)2NR15R16, —N(R15)S(═O)2R18, C3-10 cycloalkyl, C3-16 cycloalkyl-C1-6-alkyl, C2-9 heterocyclyl, C2-9 heterocyclyl-C1-6-alkyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C1-9 heteroaryl or C1-9 heteroaryl-C1-6-alkyl, and wherein optionally each of C3-10 cycloalkyl, C3-10 cycloalkyl-C1-6-alkyl, C2-9 heterocyclyl, C2-9 heterocyclyl-C1-6-alkyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C1-9 heteroaryl and C1-9 heteroaryl-C1-6-alkyl is independently substituted with one, two, three or four substituents independently selected from oxo (═O), halogen, hydroxy, mercapto, amino, nitro, cyano, C1-6 alkyl, C1-6 haloalkyl, C1-6 alkoxy, C1-6 haloalkoxy, acyl, sulfonyl, C3-10 cycloalkyl, C2-9 heterocyclyl, C6-19 aryl or C1-9 heteroaryl;
• wherein each R14, R16, R17 and R18 is independently C3-10 cycloalkyl, C3-16 cycloalkyl-C1-6-alkyl, C2-9 heterocyclyl, C2-9 heterocyclyl-C1-6-alkyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C1-9 heteroaryl or C1-9 heteroaryl-C1-6-alkyl, and wherein optionally each of C3-10 cycloalkyl, C3-10 cycloalkyl-C1-6-alkyl, C2-9 heterocyclyl, C2-9 heterocyclyl-C1-6-alkyl, C6-10 aryl, C6-10 aryl-C1-6-alkyl, C1-9 heteroaryl and C1-9 heteroaryl-C1-6-alkyl is independently substituted with one, two, three or four substituents independently selected from oxo (═O), halogen, hydroxy, amino, nitro, cyano, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, acyl or sulfonyl;
• each R15 is independently H or C1-6 alkyl, and wherein C1-6 alkyl is independently and optionally substituted with one, two, three or four substituents independently selected from oxo (═O), halogen, C1-4 alkyl, C1-4 haloalkyl, amino, C1-4 alkoxy, C1-4 haloalkyl, C3-6 cycloalkyl, C2-5 heterocyclyl, C6-16 aryl or C1-5 heteroaryl;
• R6 is H, hydroxy, mercapto, amino or C1-4 alkyl;
• R7 is H or C1-4 alkyl, and wherein C1-4 alkyl is independently and optionally substituted with one, two, three or four substituents independently selected from halogen, amino, hydroxy, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, C2-5 heterocyclyl, C6-16 aryl or C1-5 heteroaryl;
• each R8 and R9 is independently H or C1-4 alkyl, and wherein C1-4 alkyl is independently and optionally substituted with one, two, three or four substituents independently selected from halogen, amino, hydroxy, C1-4 alkyl, C1-4 alkoxy, C3-6 cycloalkyl, C2-5 heterocyclyl, C6-10 aryl or C1-5 heteroaryl;
• k is 1, 2, 3 or 4;
• each m is independently 1, 2, 3 or 4;
• each n is independently 0, 1 or 2;
• and
• each p and q is independently 0, 1, 2, 3 or 4.