Systems, devices, and methods for tissue therapy
OwnerJames C. CHEN, Llew KELTNER +1inventors
InventorsJames C. CHEN, Llew KELTNER, Alexei N. NAIMUSHIN
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Abstract
Systems, devices, and methods are described for providing, among other things, improvement in treatment of abnormal tissues including cancer, utilizing light activated drug therapy. Improvements include the use of optical penetration and drug penetration enhancers, in combination with photosensitizing drugs, and the use of localization aids and implements, which enable treatment of larger tissue volumes using minimal tissue access. The cytotoxic photoactivation process is also improved by using internal guidance to direct the light source to and at the lesion site using a naturally occurring orifice or intravascular access route.
Claims23
A medical device, comprising:
- a needle having body structure including at least one internal surface defining a passageway;
- a photo-activation assembly receivable within the passageway, the photo-activation assembly including at least one optical emitter;
- and
- an acoustic assembly receivable within the passageway, the acoustic assembly including at least one transducer operable to deliver an acoustic stimulus to one or more target regions proximate an outer surface of the needle.
A method, comprising:
- generating at one or more parameter for controlling at least one of a direction, intensity, duration, or peak emission wavelength of an illumination source responsive to acoustic information indicative of a tumor location, a tumor dimension, or tumor type;
- and
- interrogating one or more regions within a biological subject with an optical stimulus, the optical stimulus of a character and for a duration sufficient to activate one or more photosensitizers within one or more regions within a biological subject.
A photodynamic therapy composition, comprising:
- at least one photosensitizer;
- at least one tissue penetration enhancer;
- at least one optical clearing agent;
- and
- a pharmaceutical acceptable carrier.
A photodynamic therapy device, comprising:
- an optical clearing agent delivery component;
- a tissue penetration enhancer delivery component;
- and
- a photosensitizer delivery component.
Dependencies are inferred from the claim text.