Variable frequency stimulation therapy method

An electrical stimulation therapy method for neurological disease of a patient, the method comprising:

• implanting a lead in a brain of the patient so that at least one stimulation contactor of the lead contact with a target nerve tissue of the patient, wherein the patient suffers from dysfunction of a nerve circuit in the brain selected from the group consisting of motor circuit, associative circuit and limbic circuit;
• coupling the lead to a pulse generator;
• and
• applying a variable frequency stimulation pulse in a combination of at least two kinds of electrical stimulation pulse trains at different frequencies to target nerve tissue of the patient by the pulse generator and the lead;
• the at least two kinds of electrical stimulation pulse trains alternately stimulating the target nerve tissue and forming a plurality of pulse train periods;
• and each of the at least two kinds of electrical stimulation pulse trains in each of the plurality of pulse train periods has a duration in a range from about 0.1 seconds to about 60 minutes;
• wherein the target nerve tissue is part of the nerve circuit;
• the different frequencies of the electrical stimulation pulse trains are in a range from about 10Hz to about 250 Hz.