pH-MODULATING DRUG DELIVERY DEVICES AND METHODS
AssigneeTARIS Biomedical LLC
InventorHeejin Lee
Life of this patent
Estimating the term…
Abstract
Drug delivery devices and methods are provided for modulating the microenvironmental pH surrounding the device. One embodiment of a drug delivery device includes an elongated annular body formed of a matrix system containing a drug dispersed in a biocompatible polymer and a pH modifier disposed in the lumen of the body, wherein the device is configured to release in vivo (i) the drug by diffusion from the annular body and (ii) the pH modifier by diffusion through the annular body. Methods in clude inserting into the patient a device and releasing the drug and pH modifier therefrom by diffusion.
Claims32
A drug delivery device comprising:
- an elongated annular body formed of a matrix system comprising a drug dispersed in a biocompatible polymer, the elongated body having a first end, an opposed second end, and a lumen extending between the first and second ends;
- and
- a pH modifier disposed in the lumen,
- wherein the device is configured to release in vivo (i) the drug by diffusion from the annular body and (ii) the pH modifier by diffusion from the lumen through the annular body.
A drug delivery device comprising:
- an elongated annular body formed of a biocompatible polymer, the elongated body having a first end, an opposed second end, and a lumen extending between the first and second ends;
- and
- a drug and a pH modifier disposed in separate locations in the lumen,
- wherein the device is configured to release in vivo the drug and the pH modifier by diffusion from the lumen through the annular body, and
- wherein the device is configured to release the pH modifier in an amount effective to cause a proximal media pH adjacent an outer surface of the annular body to be dominated by a microenvironment pH created by the diffusion of the pH modifier and not by a macro pH of an external media.
A method of administering a drug to a patient in need thereof, comprising:
- inserting into the patient a device comprising:
- an elongated annular body formed of a matrix system comprising a drug dispersed in a biocompatible polymer, the elongated body having a first end, an opposed second end, and a lumen extending between the first and second ends;
- and
- a pH modifier disposed in the lumen;
- releasing the drug by diffusion from the annular body to the body of the patient;
- and
- releasing the pH modifier by diffusion from the lumen through the annular body to the body of the patient.
28-36. (canceled)
38-40. (canceled)
A method of administering a drug to a patient in need thereof, comprising:
- inserting into the patient a device comprising:
- an elongated annular body formed of a biocompatible polymer, the elongated body having a first end, an opposed second end, and a lumen extending between the first and second ends;
- and
- a drug and a pH modifier disposed in separate locations in the lumen;
- and
- releasing the drug and the pH modifier by diffusion from the lumen through the annular body,
- wherein the pH modifier is released in an amount effective to cause a proximal media pH adjacent an outer surface of the annular body to be dominated by a microenvironment pH created by the diffusion of the pH modifier and not by a macro pH of an external media.
42-50. (canceled)
Dependencies are inferred from the claim text.