A method for constructing nitric oxide-generating adherent coating

A method for preparing a coating having nitric oxide (NO) generating activity, wherein a composite material is formed by chemical coupling, coordination reaction and self-assembly polymerization of a compound(s) having an ortho-phenol structure, an organic selenium or sulfur compound(s), and copper ion(s), and the method comprises the following steps:

• (a) immersing the material to be modified in a buffer having a pH of 2 to 14, and then adding to the buffer system
• one or more of compounds having an ortho-phenol structure, flavones, flavonols or dihydroflavones at a concentration of 0.1 ng/mL to 100 mg/mL,
• one or more of compounds having a disulfide bond, a diselenide bond, a monosulfide bond or a monoselenide bond with a glutathione peroxidase (GPx)-like NO generating activity at a concentration of 0.1 ng/mL to 100 mg/mL, and soluble copper salt(s) at a concentration of 0 mg/mL to 100 mg/mL, and
• allowing them to react at 0-200° C. for 1 second to 10 days;
• and
• (b) washing and drying the sample obtained from step (a) successively to obtain a target modified material.