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US 2017/0246327 A1Published application
18f-tagged inhibitors of prostate specific membrane antigen (psma), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer
AssigneesDeutsches Krebsforschungszentrum, Ruprecht-Karls-UniversitäT Heidelberg
InventorsKlaus KOPKA, Martina Benesova, Jens Cardinale, Matthias Eder, Martin SCHÄFER, Ulrike BAUDER-WÜST, Uwe Haberkorn, Michael Eisenhut
Life of this patent
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Abstract
The present invention generally relates to the field of radiopharmaceuticals and their use in nuclear medicine as tracers, imaging agents and for the treatment of various disease states of prostate cancer.
Claims20
A compound of formula (Ia) or (Ib):
- with:
- n:
- 0, 1
- m:
- 0, 1, 2, 3, 4 with proviso that m + n > 0
- Z:
- —CO2H, —SO2H, —SO3H, —SO4H, —PO2H, —PO3H,
- —PO4H2
- X:
- Naphthyl, Phenyl, Biphenyl, Indolyl (=2,3-benzopyrrolyl),
- Benzothiazolyl
- Y:
- Aryl, Alkylaryl, Cyclopentyl, Cyclohexyl, Cycloheptyl
- 18F-Tag:
- With:
- x = 1-5
- Carbohydrate:
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
- R1:
- Any alkyl, aryl or arylalkyl linker
- especially methyl, 2-ethyl, 3-propyl,
- 2-, 3-, 4-phenyl, 2-, 3-, 4-phenylmethyl, 2-, 3-, 4-phenylpropyl
- R2:
- Any alkyl or aryl group
- especially methyl isopropyl, tert-butyl,
- phenyl or 1-naphtyl
70 more elements
Dependencies are inferred from the claim text.