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US 2017/0246314 A1Published application
Folate Receptor Binding Conjugates of Antifolates
AssigneesPurdue Research Foundation, Endocyte, Inc.
InventorsChristopher Paul Leamon, Iontcho Radoslavov Vlahov, Philip Stewart Low
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Abstract
Conjugates of antifolates, releasable linkers, and drugs, and pharmaceutical compositions containing them are described. The conjugates are useful for treating diseases arising from pathogenic cell populations. Methods for treating stroll diseases are also described.
Claims13
1-23. (canceled)
A method for treating a population of pathogenic cells in a patient, the method comprising administering to the patient a therapeutically effective amount of a congugate of formula ALDm, wherein A is an antifolate of the formula:
- wherein:
- (1) X═OH, R═H, and Y=Glu;
- or
- (2) X═OCH3, R═H, and Y+Glu;
- or
- (3) X═OH, R═H, and Y=Valine;
- or
- (4) X═OH, R═H, and Y=Suberate;
- or
- (5) X═OH, R═CH3, and Y=Glu;
- m is 1 to 3;
- D is an independently selected drug;
- and;
- L is a linker comprising at least one releasable linker,
11 more elements
Dependencies are inferred from the claim text.