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US 2017/0246312 A1Published application
Novel immunostimulatory method
AssigneeInnavac Pty Ltd
InventorsDAVID CHARLES JACKSON, AMABEL TAN, WEIGUANG ZENG
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Abstract
This invention relates to a method for treating or preventing a disease by raising an innate immune response in a subject, the method comprising administering to the subject an effective amount of a composition comprising a TLR2 moiety in solution, wherein the TLR2 moiety comprises a TLR2 agonist and wherein the disease is not treated or prevented by a humoral or cellular immune response directed against the TLR2 moiety.
Claims25
1-17. (canceled)
A method for preventing or treating a respiratory condition associated with one or more bacterial infectious agents in a subject, the method comprising:
- administering to the respiratory tract a composition comprising a soluble TLR2 moiety comprising a TLR2 agonist and a solubilizing agent that increases the solubility of the TLR2 agonist in polar or aqueous solvents,
- wherein the moiety does not raise an immune response in the subject that is specific for an antigen of the one or more infectious agents,
- wherein the composition does not contain a peptide antigen comprising a T-helper epitope,
- thereby preventing or treating the respiratory condition in the subject.
1 more element
26:
- The method according to claim 18, wherein the soluble TLR2 moiety is PEG-Pam2Cys.
Dependencies are inferred from the claim text.