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US 2017/0246311 A1Published application
Peptides for binding alternatively activated macrophages
OwnerSuzie H. PUN, Mary Elise CIESLEWICZ +1inventors
InventorsSuzie H. PUN, Mary Elise CIESLEWICZ, Chayanon NGAMBENJAWONG
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Abstract
M2 macrophage-binding peptides and polymers and related methods of use are described.
Claims20
A peptide comprising contiguous amino acid residues according to the formula:
- X0-X1-D-P*-W-X2-X3-X4-X5-W*-X6-X7
- wherein
- X0 is absent or an N-terminal functional group;
- X1 is 1-7 contiguous amino acid residues;
- P* is P or hydroxyproline;
- X2 is a single amino acid;
- X3 is a single amino acid;
- X4 is a single amino acid;
- X5 is a single amino acid;
- W* is W or w;
- X6 is 1-6 contiguous amino acid residues;
- and
- X7 is absent, KKK, or kkk,
- wherein when X1 is YEQ, X0 is an N-terminal functional group;
- wherein the peptide is linear or is a cyclic peptide;
- and
- wherein when the peptide is a cyclic peptide, one residue of X1 is covalently bound to one residue of X6, optionally through a linker L.
14 more elements
A peptide comprising contiguous amino acid residues according to the formula:
- X91-X92-X93-X94-X95-X96-X97-X98-X99
- wherein
- X91 is 0-2 contiguous amino acid residues;
- X92 is a single amino acid;
- X93 is a single amino acid;
- X94 is 0-1 contiguous amino acid residues;
- X95 is a single amino acid;
- X96 is a single amino acid;
- X97 is 0-4 contiguous amino acid residues;
- X98 is a single amino acid;
- and
- X99 is 0-5 contiguous amino acid residues;
- and
- and wherein at least one of the following applies:
- X92 is W, X93 is P, and X96 is D;
- X93 is P, X95 is S, and X98 is A;
- X93 is P, X95 is S, and X98 is L;
- or
- X92 is W, X93 is V, X96 is D, and X98 is W.
16 more elements
A polymer comprising two or more repeating units that form a backbone, wherein the repeating units comprise at least one unit comprising a conjugated M2 macrophage-binding peptide and optionally one or more unconjugated units.
Dependencies are inferred from the claim text.