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US 2017/0246306 A1Published application
Derivatives obtained from hyaluronic acid and carnosine
AssigneesSebastiano SCIUTO, Consiglio Nazionale Delle Ricerche, Fidia Farmaceutici S.P.A.
InventorsSebastiano SCIUTO, Valentina GRECO, Enrico RIZZARELLI, Francesco BELLIA, Valeria LANZA, Susanna VACCARO, Luciano MESSINA
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Abstract
The present invention relates to a derivative of carnosine (β-alanyl-L-histidine) having formula (1), obtained by the functionalization of hyaluronic acid with carnosine.
Claims20
A compound having formula (1)
- conjugate of carnosine dipeptide having formula (2)
- with hyaluronic acid, wherein the conjugation is effected by the formation of an amide bond between the NH2 group of carnosine, preferably protected at the carboxyl group, and one or more carboxylic groups of hyaluronic acid, preferably of an active derivative of hyaluronic acid, even more preferably a COX ester having formula (3)
Dependencies are inferred from the claim text.