Method for introducing exogenous substance into cell, and material used in said method
AssigneesToagosei Co., Ltd., Osaka Prefecture University Public Corporation
InventorsIkuhiko Nakase, Tetsuhiko Yoshida, Nahoko Baileykobayashi
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Abstract
Provided is a novel material used to introduce an exogenous substance into cells. Also provided is a method for introducing an exogenous substance into target cells using this material. The present invention provides an exosome that is used to introduce an exogenous substance into target cells, wherein the exosome contains one type or two or more types of an exogenous substance and a substance that induces macropinocytosis in the target cells. The present invention also provides a composition containing the exosome and a method for introducing an exogenous substance into cells using this exosome.
Claims12
An artificial exosome for introducing an exogenous substance into a target cell from outside the target cell, the exosome comprising:
- at least one exogenous substance, and
- a substance that induces macropinocytosis in the target cell.
A composition for introducing an exogenous substance into a target cell from outside the target cell, the composition comprising:
- a pharmaceutically acceptable carrier,
- a substance that induces macropinocytosis in the target cell,
- an artificial exosome;
- and
- at least one exogenous substance;
- wherein the exogenous substance is contained in the exosome.
A method for introducing an exogenous substance into a target cell in vitro, the method comprising:
- preparing a cell culture containing the target cell, and
- supplying an artificial exosome, wherein the exosome comprises at least one exogenous substance and a substance that induces micropinocytosis in the target cell.
Dependencies are inferred from the claim text.