Compositions and methods for treatment of pre-cancerous skin lesions
AssigneeWashington University
InventorsLynn Cornelius, Shadmehr Demehri, Raphael Kopan
Life of this patent
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Abstract
The present disclosure encompasses compositions and methods for the treatment of precancerous skin lesions. Compositions of the invention comprise a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
Claims20
A method to treat a precancerous skin lesion, the method comprising topically administering to the lesion a composition comprising a cytotoxic agent and a thymic stromal lymphopoietin (TSLP) inducer.
A method to prevent the transition of a precancerous skin lesion to skin cancer, the method comprising:
- a) identifying a subject with one or more precancerous skin lesion(s);
- and
- b) topically administering to the precancerous skin lesion(s) a composition comprising a cytotoxic agent and a TSLP inducer, wherein the precancerous skin lesion(s) is reduced in size such that progression to skin cancer is prevented.
A method to prevent a precancerous skin lesion from occurring, the method comprising topically administering to a subject at risk of developing a precancerous skin lesion a composition comprising a cytotoxic agent and a TSLP inducer.
Dependencies are inferred from the claim text.