Attenuated Mannheimia haemolytica Vaccines and Methods of Making and Use
AssigneeMerial Limited
InventorsRussell F. Bey, Paulraj Kirubakaran Lawrence, Randy R. Simonson
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Abstract
The present invention provides attenuated M. haemolitica strains that elicit an immune response in animal against M. haemolitica, compositions comprising said strains, methods of vaccination against M. haemolitica, and kits for use with such methods and compositions. The invention further provides multi-valent vaccines, which provide protective immunity when administered in an effective amount to animals susceptible to “shipping fever” or bovine respiratory disease.
Claims20
1-23. (canceled)
A non-adjuvanted, intranasal vaccine comprising an attenuated Mannheimia haemolytica (M. haemolytica) A1 strain and an attenuated M. haemolytica A6 strain, which vaccine provides a safe and protective immune response in a bovine animal against both M. haemolytica strains A1 and A6, or diseases caused by M. haemolytica strains A1 and A6.
Dependencies are inferred from the claim text.