Staphylococcus aureus materials and methods
AssigneeThe Regents of the University of Michigan
InventorsJon Oscherwitz, Kemp Cease
Life of this patent
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Abstract
The disclosure generally relates to the field of prevention and treatment of Staphylococcus aureus infections. In particular, the disclosure relates to immunogens comprising Staphylococcus aureus antigens and methods for generating immune responses to immunogens, and to antibody products specific for the Staphylococcus aureus epitopes and methods for treating Staphylococcus aureus infection with the antibody products.
Claims21
An immunogenic composition comprising an immunogen consisting essentially of the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1) or an immunogenic equivalent thereof.
A method of inducing an immune response to S. aureus alpha toxin in a subject comprising administering an immunogenic composition to the subject in an amount effective to induce protective immunity against S. aureus infection, wherein the immunogenic composition comprises an immunogen consisting essentially of the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1) or an immunogenic equivalent thereof.
A method of treating S. aureus infection in a subject comprising administering an immunogenic composition to the subject, wherein the immunogenic composition comprises an immunogen consisting essentially of the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1) or an immunogenic equivalent thereof.
A method of treating S. aureus infection in a subject comprising administering to the subject an antibody product specific for the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1).
An antibody product specific for the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1).
A method of treating S. aureus infection in a subject comprising administering to the subject a polynucleotide encoding an antibody product specific for the S. aureus alpha toxin epitope GFNGNVTGDDTGKIGGLIGAN (SEQ ID NO:
- 1).
Dependencies are inferred from the claim text.