US 2017/0246271 A1 · INNATE IMMUNE MODULATING MOLECULE COMPLEX FOR THE ACTIVATION OF THE INNATE IMMUNE SYSTEM OF AQUATIC ANIMALS AND METHODS THEREFOR

Abstract

A method for application of an innate immune modulating molecule complex to activate the innate immune system of aquatic animals includes selecting a recombinant DNA with characteristics configured for activating aquatic animal macrophages, such as by inducing an innate immune response in the animal. The method for application of an innate immune modulating molecule complex also includes selecting an adjuvant with characteristics favorable for activating aquatic animal macrophages and causing the release of cytokines. The stimulant recombinant DNA is combined with the adjuvant to form an innate immune modulating molecule (I2M2 complex). The I2M2 complex induces a synergistic response in macrophages that causes activation and proliferation of macrophages, expulsion of or inhibition of pathogens from the macrophages, and release of cytokines that aid in normal innate and acquired immune responses of fish.

Claims20

Dependent claims

An innate immune modulating molecule complex, comprising:

a supercoiled covalently closed recombinant plasmid DNA, where the supercoiled covalently closed recombinant plasmid DNA comprises characteristics configured for inducing an innate immune response in aquatic animals;
and
an adjuvant complexed with the supercoiled covalently closed recombinant plasmid DNA, where the adjuvant comprises characteristics configured for inducing cytokine release from macrophages in aquatic animals.

Dependencies are inferred from the claim text.

Facts

Application

15/509,634Filed 8 Sep 2015

Priority

8 Sep 2014

Published

31 Aug 2017

Term ends

Not estimatedThe source records don’t support an estimate.

Classification12 codes

A61K 39/0005
Medicinal preparations containing antigens or antibodies: vertebrate antigens
A61K 31/713
Compounds having three or more nucleosides or nucleotides: double-stranded nucleic acids or oligonucleotides
A61K 39/39
Medicinal preparations containing antigens or antibodies: characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 48/00
Medicinal preparations containing genetic material which is inserted into cells of the

Innate immune modulating molecule complex for the activation of the innate immune system of aquatic animals and methods therefor

Life of this patent

Innate immune modulating molecule complex for the activation of the innate immune system of aquatic animals and methods therefor

Life of this patent

Abstract

Claims20