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US 2017/0246270 A1Published application
Peptidic chimeric antigen receptor t cell switches and uses thereof
AssigneeThe California Institute for Biomedical Research
InventorsTravis YOUNG, Chanhyuk KIM, Peter G. SCHULTZ
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Abstract
Disclosed herein are chimeric antigen receptor effector cells (CAR-ECs) and CAR-EC switches. The switchable CAR-ECs are generally T cells. The one or more chimeric antigen receptors may recognize a peptidic antigen on the CAR-EC switch. The CAR-ECs and switches may be used for the treatment of a condition in a subject in need thereof.
Claims26
-62. (canceled)
A method comprising:
- a. administering a first chimeric antigen receptor-effector cell (CAR-EC) switch to a subject, wherein the first CAR-EC switch comprises:
- a. a first linear peptidic antigen that binds a chimeric antigen receptor on an effector cell;
- and
- b. a first targeting moiety that binds a cell surface molecule on a target cell;
- and
- b. administering a first chimeric antigen receptor-effector cell comprising a chimeric antigen receptor that binds to the peptidic antigen of the chimeric antigen receptor-effector cell switch.
3 more elements
Dependencies are inferred from the claim text.