Cholinergic antagonism as an adjunct to cancer therapy
AssigneesThe Trustees of Columbia University in the City of New York, Norwegian University of Science and Technology
InventorsTimothy C. WANG, Duan CHEN, Chun-Mei ZHAO
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Abstract
The invention provides for methods for treating gastric cancer or colon cancer in a subject by administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, or performing a surgical denervation. The invention provides for inhibiting stem cells growth by administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, or performing a surgical denervation. The invention provides for stimulating regeneration of the colon or stomach by administering a cholinergic agonist.
Claims24
A method for treating gastric or colon cancer in a subject in need thereof, the method comprising administering to the subject a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, performing surgical denervation on the subject, or a combination thereof.
A method for reducing or inhibiting proliferation of gastric or colon tumor cells, the method comprising administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, performing surgical denervation, or a combination thereof.
A method for inhibiting stem cell growth, the method comprising administering a cholinergic antagonist, a Botulinum toxin, a NGF inhibitior, a TRK inhibitor, performing surgical denervation, or a combination thereof.
A method for stimulating growth of stem cells, the method comprising administering a cholinergic agonist.
A method for stimulating regeneration of the colon or stomach in a subject in need thereof, the method comprising administering to the subject a cholinergic agonist.
A method for treating colitis or gastritis in a subject in need thereof, the method comprising administering to the subject a cholinergic agonist.
A method for treating radiation-induced gastrointestinal syndrome (RIGS) in a subject in need thereof, the method comprising administering to the subject a cholinergic agonist.
Dependencies are inferred from the claim text.