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AssigneesProcell Therapeutics Inc., Atgc Inc.
InventorsByung Kyu Lee, Kang Jin Lee, Min Joong Kim, Hong Gyu Park
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The present invention relates to: a novel cell penetrating peptide; a cell penetrating botulinum toxin recombinant protein composition in which the cell penetrating peptide and the light chain of a botulinum toxin are fused; and a use thereof and, more specifically, to a composition enabling the transdermal delivery of a cell penetrating botulinum toxin recombinant protein and capable of being locally used for various treatments of the skin and cosmetic purposes. The cell penetrating peptide-botulinum toxin recombinant protein of the present invention can be transdermally delivered, thereby having the intrinsic effect of a botulinum toxin and simultaneously having greater convenience of use, and thus can be effectively applied as a local agonist for the treatment of various diseases and aesthetic and/or cosmetic purposes.
A cell-penetrating peptide, which is a peptide capable of mediating the delivery of a biologically active molecule into cells, the peptide consisting of an amino acid sequence of SEQ. ID. NO:
A cell-penetrating botulinum toxin recombinant protein in which a cell-penetrating peptide consisting of an amino acid sequence of SEQ. ID. NO:
16-20. (canceled)
Dependencies are inferred from the claim text.